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DeCS
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Descriptor English:
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Tetrahydrofolate Dehydrogenase
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Descriptor Spanish:
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Tetrahidrofolato Deshidrogenasa
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Descriptor Portuguese:
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Tetra-Hidrofolato Desidrogenase
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Synonyms English:
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Acid Reductase, Folic
Dehydrogenase, Dihydrofolate
Dehydrogenase, Tetrahydrofolate
Dihydrofolate Dehydrogenase
Dihydrofolate Reductase
Folic Acid Reductase
Reductase, Dihydrofolate
Reductase, Folic Acid
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Tree Number:
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D08.811.682.662.825
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Definition English:
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An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3. |
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Entry Combination - descr/qualif English:
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Tetrahydrofolate Dehydrogenase/antagonists & inhibitors use Folic Acid Antagonists
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History Note English:
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66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
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Allowable Qualifiers English:
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Record Number:
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14141
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Unique Identifier:
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D013762
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Occurrence in VHL:
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Similar:
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DeCS
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